According to the Market Statsville Group (MSG), the Global GERD and NERD Treatment Market size was valued at USD 2,628.7 million in 2023 and is expected to grow from USD 2,822.5 million in 2024 to USD 5,293.1 million by 2033, by exhibiting a CAGR of 7.9% during the forecast period (2024-2033). 

The therapeutic market of GERD and NERD has a wide variety of pharmaceutical and non-pharmaceutical treatment modalities, which are directed at symptom management and the prevention of adverse events related to acid-back diffusion. Pharmacotherapy generally includes the use of proton pump inhibitors and H2-receptor antagonists, which understandably inhibit acid production by the stomach. Non-pharmacotherapy includes lifestyle treatments: diet, body mass index, and to a certain degree, elevating the head during sleep. Market growth will be on the upsurge as the incidence of GERD and NERD, globally prompted by various lifestyle modifications, dietary habits, and obesity, is increasing. 

The market growth for the industry also depends on technological advancement in diagnostics techniques and various advanced treatment options along with increasing awareness and healthcare expenditure. The market environment consists of major players that are creating new therapies and devices to meet the various patient needs and demands by significantly concentrating on the effectiveness and safety profiles of existing treatments.

Definition of the GERD and NERD Treatment

Gastroesophageal reflux disease (GERD) and non-erosive reflux disease (NERD) are syndromes caused by chronic acid exposure from the stomach to the esophagus. The common feature is that GERD has the characteristic of erosive damage in the esophageal mucosa appearing in endoscopy, whereas NERD has similar symptoms but does not show visible symptoms of mucosal erosions. Symptoms occurring in both include heartburn and regurgitation, and they might bring about complications such as esophagitis and Barrett.

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Scope of the Global GERD and NERD Treatment Market 

The study categorizes the GERD and NERD Treatment market based on drug class, dosage form, and end-users area at the regional and global levels.

By Drug Class Outlook (Sales, USD Million, 2019-2033)

• Antacids
• H2 Receptor Blocker
• Proton Pump Inhibitors 
• Others

By Dosage Form Outlook (Sales, USD Million, 2019-2033)

• Solid
• Liquid
• Others

By End-Users Outlook (Sales, USD Million, 2019-2033)

• Hospitals
• Clinics
• Research Centers
• Others 

By Region Outlook (Sales, USD Million, 2019-2033)

• North America 
  • US
  • Canada
  • Mexico
• Europe 
  • Germany
  • Italy
  • France
  • UK
  • Spain
  • Poland
  • Russia
  • The Netherlands
  • Norway
  • Czech Republic
  • Rest of Europe
• Asia Pacific 
  • China
  • Japan
  • India
  • South Korea
  • Indonesia
  • Malaysia
  • Thailand
  • Singapore
  • Australia & New Zealand
  • Rest of Asia Pacific
• South America
  • Brazil
  • Argentina
  • Colombia
  • Rest of South America
• The Middle East & Africa
  • Saudi Arabia
  • UAE
  • South Africa
  • Northern Africa
  • Rest of MEA

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Proton pump inhibitors segment accounts for the largest market share by drug class

Based on the drug class, the market is divided into the Antacids, H2 Receptor Blocker, and Proton Pump Inhibitors segment. The proton pump inhibitors accounted for the largest market share in the global GERD and NERD Treatment market. PPIs are prescribed quite commonly for their potent effects at suppressing acid to manage symptoms and promote the healing of esophageal erosions associated with both GERD and NERD. Their very effective mode of action is the final inhibition of acid production in the stomach, superior to H2 receptor blockers and antacids for controlling gastric acid secretion over the long term. Besides, PPIs are usually well-tolerated and have a favorable safety profile if applied properly; these are some reasons the wide acceptance and dominance of their use have propagated in treating these gastrointestinal disorders. 

North America accounted for the largest market share by Region

Based on the regions, the global market of GERD and NERD Treatment has been segmented across North America, Europe, the Middle East & Africa, South America, and Asia-Pacific. North America holds a leading position in the market for the treatment of GERD and NERD because of several advantageous factors. This is because the disease is highly prevalent based on dietary patterns, obesity rates, and lifestyle factors dominant in the general population of this region. Advanced healthcare infrastructure and significant investments in research and development further augment diagnostic capabilities and treatment options, driving market growth. 

North America houses companies that top in the number of present novel therapies developed due to company-friendly regulations and high market demand for such matters. Besides, high expenditure on therapies and considerable insurance coverage for the same support the access by patients to new treatments and therapies. All these make up a very enabling environment to foster dominance in the market, thereby placing North America at the leading edge in tackling the rising healthcare needs associated with GERD and NERD management.

Competitive Landscape: Global GERD and NERD Treatment Market 

The global GERD and NERD therapeutic market is highly competitive, with major pharmaceutical companies easily inventing agents for a standard cure. The key players in this sector therefore are involved in the development of new treatments and increasing the efficiency of treatment, which remains challenged by several side effects and low rate of adherence to the medication. This further lays the groundwork for technological developments and strategic cooperation.

Major players in the global GERD and NERD Treatment market are: 

• EndoStim
• EndoGastric Solutions
• Ironwood Pharmaceuticals    
• GlaxoSmithKline
• Mederi Therapeutics
• Jeil pharmaceutical
• Johnson & Johnson
• Medtronic
• Medigus
• Novartis
• Merck
• Takeda Pharmaceutical
• Pfizer
• Torax Medical
• Teva Pharmaceuticals
• Allegiant health
• Bausch Health
• Carbon Medical
• Sanofi
• Tya pharmaceuticals

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 Recent Developments 

• In March 2024, AstraZeneca has signed an agreement to acquire Amolyt Pharma, a clinical-stage biotechnology company. The focus of Amolyt Pharma's work is on the development and discovery of novel treatments for rare endocrine diseases.
• In January 2024, Boston Scientific Corporation announced that it has entered into a definitive agreement to acquire Axonics, Inc., a medical technology company that designs, develops, and commercializes novel medical devices for the treatment of intestinal and urinary disorders. The enterprise value comes out at approximately $3.4 billion, and an equity value is about $3.7 billion, thereby reflecting the acquisition price of $71 in cash per share.