The RNA Interference (RNAi) Nucleic Acid Therapeutics Market Report provides a detailed assessment of the market, examining size, trends, and growth opportunities. It highlights the influence of technology, consumer behavior, and competitive strategies on market evolution. The study offers a thorough analysis of leading players, their product offerings, and market positioning.

This report explores regional and application-based segmentation, identifying growth hotspots and emerging areas of opportunity. It also addresses market challenges, regulatory concerns, and potential risks, offering a realistic outlook for businesses and investors.

RNA Interference (RNAi) Nucleic Acid Therapeutics Market Size

• The global RNA Interference (RNAi) nucleic acid therapeutics market size was valued at USD 2.22 billion in 2024 and is expected to reach USD 3.86 billion by 2032, at a CAGR of 7.13% during the forecast period
• The market growth is largely fueled by the growing adoption and technological progress within RNA-based drug discovery and gene-silencing platforms, leading to increased development of targeted therapies in both rare and chronic disease segments. RNA interference (RNAi) technology enables precise silencing of specific genes, which is revolutionizing treatment strategies in oncology, metabolic disorders, and genetic diseases
• Furthermore, rising demand for safe, efficient, and personalized therapeutic solutions is establishing RNAi-based drugs as a transformative class of therapeutics. These converging factors are accelerating the uptake of RNA Interference (RNAi) nucleic acid therapeutics solutions, thereby significantly boosting the industry's growth. The increasing number of clinical trials, successful FDA approvals (such as Patisiran and Givosiran), and partnerships between biotech firms and large pharmaceutical companies further underscore the rapid momentum in this market

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RNA Interference (RNAi) Nucleic Acid Therapeutics Market Analysis

• RNAi therapeutics, offering targeted gene-silencing mechanisms, are increasingly vital components of modern precision medicine, particularly in treating genetic disorders, cancers, and rare diseases. Their ability to specifically inhibit the expression of disease-causing genes is revolutionizing treatment approaches across both clinical and research settings.
• The escalating demand for RNA Interference (RNAi) nucleic acid therapeutics is primarily fueled by the growing prevalence of chronic and genetic diseases, advancements in oligonucleotide delivery systems, and strong pipeline developments by leading pharmaceutical companies. In Addition, favorable regulatory support and rising R&D investment are contributing to accelerating the commercialization of RNAi-based therapies
• North America dominated the RNA Interference (RNAi) Nucleic Acid Therapeutics market with the largest revenue share of 45.7% in 2024, driven by robust healthcare infrastructure, early adoption of advanced therapeutics, high healthcare expenditure, and strong presence of key industry players such as Alnylam Pharmaceuticals and Arrowhead Pharmaceuticals
• Asia-Pacific is expected to be the fastest-growing region in the RNA Interference (RNAi) Nucleic Acid Therapeutics market during the forecast period, with a projected CAGR of 17.4%, attributed to improving healthcare systems, growing investments in biotechnology, and increasing collaborations between regional pharmaceutical firms and global RNAi drug developers
• The Small Interfering RNA (siRNA) segment dominated the RNA Interference (RNAi) Nucleic Acid Therapeutics market with a market share of 61.3% in 2024, owing to its proven clinical efficacy, well-established delivery systems, and higher number of FDA-approved therapies. siRNA-based drugs such as Onpattro and Givlaari have paved the way for expanding RNAi drug pipelines globally

RNA Interference (RNAi) Nucleic Acid Therapeutics Market Scope

The market is segmented on the basis of type, route of administration, indication, end user, and application.

• By Type

On the basis of type, the RNA Interference (RNAi) nucleic acid therapeutics market is segmented into small interfering RNA (siRNA) and MicroRNA (miRNA). The small interfering RNA (siRNA) segment held the largest market revenue share of 61.3% in 2024, owing to its advanced therapeutic development stage, higher clinical success rates, and broader application in rare genetic diseases and liver-based disorders. siRNA-based therapies such as Onpattro and Givlaari have already received regulatory approval, driving commercial momentum.

The miRNA segment is projected to witness the fastest growth rate from 2025 to 2032, driven by its emerging role in modulating gene expression in cancer and metabolic disorders, with expanding research initiatives and early-phase clinical trials showing encouraging outcomes.

• By Route of Administration

On the basis of route of administration, the market is segmented into Intravenous, intradermal, pulmonary delivery, intrathecal, and others. The intravenous segment held the largest share in 2024, due to its established use in delivering siRNA therapeutics directly into systemic circulation, particularly in clinical settings.

The pulmonary delivery segment is anticipated to exhibit the fastest CAGR during the forecast period, as research advances in inhalation-based delivery systems promise more targeted and non-invasive RNAi therapy for respiratory diseases.

• By Indication

On the basis of indication, the market is segmented into acute hepatic porphyria (AHP), hereditary transthyretin-mediated amyloidosis (hATTR), hypercholesterolemia, and others. The hereditary transthyretin-mediated amyloidosis (hATTR) segment accounted for the highest market revenue in 2024, supported by commercial success of RNAi therapies such as Onpattro and Amvuttra.

The hypercholesterolemia segment is forecasted to grow at the highest CAGR from 2025 to 2032, driven by the promising clinical performance of investigational RNAi therapies targeting PCSK9 and other lipid-related pathways.

• By End User

On the basis of end user, the market is segmented into hospitals & clinics, research & academic institutes, pharmaceutical & biotechnology companies, and others. The hospitals & clinics segment held the dominant revenue share in 2024, given the current administration of RNAi therapies under clinical supervision and the management of rare diseases in specialty centers.

The pharmaceutical & biotechnology companies segment is expected to grow at the highest CAGR, owing to heightened investment in RNAi R&D, expanding pipelines, and strategic partnerships aimed at drug development and commercialization.

• By Application

On the basis of application, the market is segmented into genetic disorders, oncology, neurodegenerative disorders, infectious diseases, and others. The genetic disorders segment led the market in 2024, due to the high unmet need in rare genetic diseases and the precision targeting capability of RNAi.

Oncology is projected to be the fastest-growing application segment, driven by the increasing use of RNAi to silence cancer-causing genes and ongoing clinical trials exploring its potential in solid tumors and hematologic malignancies.

The RNA Interference (RNAi) Nucleic Acid Therapeutics industry is primarily led by well-established companies, including:

• Alnylam Pharmaceuticals, Inc. (U.S.)
• Ionis Pharmaceuticals, Inc. (U.S.)
• Arrowhead Pharmaceuticals, Inc. (U.S.)
• Silence Therapeutics (U.K.)
• Arcturus Therapeutics, Inc. (U.S.)
• Sirnaomics (U.S.)
• OliX Pharmaceuticals, Inc. (South Korea)
• Arbutus Biopharma (U.S.)
• Vir Biotechnology, Inc. (U.S.)
• Wave Life Sciences (U.S.)
• Switch Therapeutics (U.S.)

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