According to the Market Statesville Group (MSG), the Global Monoclonal Antibodies Market size was valued at USD 181.50 million in 2023 and is expected to grow from USD 199.65 million in 2024 to USD 470.76 million by 2033, by exhibiting a CAGR of 10% during the forecast period (2024-2033)

The monoclonal antibodies market is growing rapidly with wide applications in various therapeutic areas such as autoimmune diseases, infectious diseases, inflammatory disorders, and oncology Compared to conventional therapies, these antibodies are designed for specific antigens that provide better recovery for patients with fewer complications: The market that is growing rapidly due to rapid emergence and increased R&D efforts exists, and investments are coming from biotechnology and pharmaceutical companies.

Major companies focus on developing therapies using monoclonal antibodies, expanding their product lines, exploiting new opportunities, and addressing unmet medical needs Also, the regulation including healthcare increasing costs drives the growth of the global market for monoclonal antibodies.
Definition of the Monoclonal Antibodies

Monoclonal antibodies are not real antibodies. Instead of being produced from within humans, they are created in settings outside the body (a laboratory). On the other hand, they can be referred to as lab–produced proteins designed to attack very specific kinds of cells by intertwining with them.

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Scope of the Global Monoclonal Antibodies Market 

The study categorizes the Monoclonal Antibodies market based on production methods, source, By therapeutic area, indications and end-users area, at the regional and global levels.

By Production Methods Outlook (Sales, USD Million, 2019-2033)

• In Vivo
• In Vitro 

By Source Outlook (Sales, USD Million, 2019-2033)

• Murine
• Chimeric
• Humanized
• Human 

By Therapeutic Area Outlook (Sales, USD Million, 2019-2033)

• Oncology
• Immunology
• Cardiology
• Neurology
• Others

By End-Users Outlook (Sales, USD Million, 2019-2033)

• Hospitals
• Specialty Clinics
• Research Institutes
• Other End Users

By Indications Outlook (Sales, USD Million, 2019-2033)

• Infectious Diseases
• Cancer
• Autoimmune Diseases
• Inflammatory Diseases
• Others

By Region Outlook (Sales, USD Million, 2019-2033)

• North America 
  • US
  • Canada
  • Mexico
• Europe 
  • Germany
  • Italy
  • France
  • UK
  • Spain
  • Poland
  • Russia
  • The Netherlands
  • Norway
  • Czech Republic
  • Rest of Europe
• Asia Pacific 
  • China
  • Japan
  • India
  • South Korea
  • Indonesia
  • Malaysia
  • Thailand
  • Singapore
  • Australia & New Zealand
  • Rest of Asia Pacific
• South America
  • Brazil
  • Argentina
  • Colombia
  • Rest of South America
• The Middle East & Africa
  • Saudi Arabia
  • UAE
  • South Africa
  • Northern Africa
  • Rest of MEA

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Monoclonal antibodies segment accounts for the largest market share by indication

Based on the application, the market is divided into Infectious Diseases, Cancer, Autoimmune Diseases, Inflammatory Diseases, and Others.  Cancer is the dominant segment of the Monoclonal Antibodies market.  Since the growth of cancer rates around the world has caused an increased number of people to come down with the disease, the cancer monoclonal antibodies application could take a substantial proportion in the global monoclonal antibody market. These are very particular to cancer cells because they bind to proteins at the surface of cancerous cells, triggering an immune response. For instance, in 2020, cancer was responsible for about 10 million deaths globally, according to the World Health Organization's (WHO) February 2022 update. Breast (2.26 million cases), lung (2.21 million cases), colon and rectum (1.93 million cases), prostate (1.41 million cases), skin (non-melanoma) (1.20 million cases), and stomach (1.09 million cases) were the most common cancer types in 2020.
In addition, gaining authorizations for multiple new cancer monoclonal antibodies from the relevant bodies is now easier, and more efficient. For instance, in January 2021, the European Union gave a conditional endorsement of trastuzumab deruxtecan as monotherapy for adult patients suffering from metastatic or incurable HER2-positive breast cancer. Therefore, The market for cancer monoclonal antibodies might expand as a result of these improvements.

North America accounted for the largest market share by Region.

Based on the regions, the global market of Monoclonal Antibodies has been segmented across North America, Europe, the Middle East & Africa, South America, and Asia-Pacific. In 2023, North America dominates the market for monoclonal antibodies for several key reasons. The first one is driving innovations in monoclonal antibody therapies. Some of the renowned industries in this category are Johnson & Johnson, as well as Pfizer, and Ely Lily. In North America, there are several companies and related institutions that have been working on making monoclonal antibodies for some period but they are not successful. They are for instance Vir Biotechnology, Inc. and GlaxoSmithKline plc declared that the US Food and Drug Administration had altered the Emergency Use Authorization (EUA) Fact Sheet for the investigational monoclonal antibody sotrovimab in March 2022. This implies that market growth in this space could be fueled by an increasing incidence of chronic conditions like cancer. In the US alone, according to the GLOBOCAN 2020 report, there were 612,390 cancer-related deaths and 2,281658 new cases of cancer diagnosed. In Canada and Mexico, there were 274364 and 195499 cases of cancer respectively.

Competitive Landscape: Global Monoclonal Antibodies Market 

Among other global monoclonal antibody market key competitors are Johnson & Johnson, Pfizer, Novartis, GlaxoSmithKline, and Eli Lilly which engage in fierce competition. These companies invest heavily in R&D to improve their products as well as come up with new ones. The dynamics in this market are characterized by an increasing need for targeted therapies across various therapeutic areas. Strategic partnerships, acquisitions, or new product introductions represent common strategies used to gain a competitive edge.

Major players in the global Monoclonal Antibodies market are: 

• Johnson & Johnson Private Limited (U.S.)
• Pfizer Inc. (U.S.)
• Novartis AG (Switzerland)
• GlaxoSmithKline plc (U.K.)
• Eli Lilly and Company (U.S.)
• Amgen Inc. (U.S.)
• AbbVie Inc. (U.S.)
• Sanofi (France)
• Bristol-Myers Squibb Company (U.S.)
• AstraZeneca (U.K.)
• F. Hoffmann-La Roche Ltd. (Switzerland)
• Biogen (U.S.)
• Other Major Players

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Recent Development 

• In March 2022, Sanofi S.A. signed a collaboration agreement with Blackstone Life Sciences for an accelerated development process in a subcutaneous formulation of Sarclisa mAb for the treatment of multiple myeloma.
• In February 2022, The FDA approved an antibody, bebtelovimab, which demonstrates neutralization against the Omicron variant for emergency use, Eli Lilly and Company announced in a news release. Bebtelovimab is an IgG1 mAb neutralizing SARS-CoV-2 spike protein.