Druid – The shapeshifting Mastery excels with Storm Werebear, offering massive DPS, excellent survivability, and flexibility through Last Epoch gold forms like Spriggan or Swarmblade. Its primary weakness is speed; while durable and deadly, it's not the fastest farmer. Still, for players who enjoy tanky, hard-hitting shapeshifters, Druid is one of the best all-around options.

B-Tier: Lich, Marksman, Beastmaster

Solid but flawed, these Masteries can shine in certain builds but generally fall short compared to A-Tier.

Lich – Built around sacrificing life for damage, Lich excels with Reaper Form and Death Seal. It offers high damage potential and sustain, but comes at the cost of safety, as constant health drain makes it risky. The passive tree has powerful damage nodes, though defenses remain limited.

Marksman – The archetypal archer. With strong builds like Hail of Arrows and Heartseeker, Marksman delivers consistent ranged DPS. Sustain through health on hit is excellent, but its defenses are paper-thin compared to Rogue counterparts. It's fun and viable, but requires careful play.

Beastmaster – A summoner Mastery that thrives with pets like Storm Crows and Wolves. It offers good, clear, and bossing potential but suffers from clunky scaling and slow movement. Strong in group play or for those who enjoy minion builds, but not a meta frontrunner.

C-Tier: Necromancer, Runemaster, Forge Guard

Playable but underwhelming compared to higher-tier picks.

Necromancer – Another summoner, but focused on undead minions. Skills like Dread Shade and Summon Wraith offer respectable DPS, yet defenses rely heavily on minions tanking for you. Snapshotting tricks can push performance higher, but it feels inconsistent compared to Beastmaster.

Runemaster – A creative caster archetype built around the Rune of Invocation. Its hybrid spell-crafting system is unique and capable of high DPS, but survivability is a serious concern. With effort, it can shine, but it's mechanically demanding and unforgiving.

Forge Guard – Tanky and thematic, Forge Guard has tools like Manifest Armor and Smelter's Wrath, but lacks the raw power or utility of top picks. It can work as a niche armor-stacking build, but it doesn't compete well against Paladin or Void Knight.

D-Tier: Spellblade, Warlock, Sorcerer

Still viable (all Masteries are), but they lag behind across the board.

Spellblade – Fast and flashy, combining melee with magic. While it has strong DPS options like Enchant Weapon and Shatter Strike, its defenses are weak, making it prone to one-shots. Fun, but punishing.

Warlock – Focused on curses and damage over time, Warlock is accessible for new players but lacks late-game scaling. Builds like Witchfire or Bleed can function, yet defensively, they offer little compared to cheap Last Epoch gold stronger Masteries.